Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.11.001
Abstract: Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are clonal stem cell disorders, primarily affecting patients over 65 years of age. Mapping of the MDS and MDS/MPN genome identified recurrent heterozygous mutations in the RNA… read more here.
Keywords: murine models; modeling human; human rna; sf3b1 srsf2 ... See more keywords
The Case for Modeling Human Infection in Zebrafish.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in microbiology"
DOI: 10.1016/j.tim.2019.08.005
Abstract: Zebrafish (Danio rerio) larvae are widely recognized for studying host-pathogen interactions in vivo because of their optical transparency, genetic manipulability, and translational potential. The development of the zebrafish immune system is well understood, thereby use of… read more here.
Keywords: human infection; infection zebrafish; modeling human; case modeling ... See more keywords
A new investigation on fractionalized modeling of human liver
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-51430-y
Abstract: This study focuses on improving the accuracy of assessing liver damage and early detection for improved treatment strategies. In this study, we examine the human liver using a modified Atangana-Baleanu fractional derivative based on the… read more here.
Keywords: human liver; investigation fractionalized; model; new investigation ... See more keywords
Optimization of micro-fabricated porous membranes for intestinal epithelial cell culture and in vitro modeling of the human intestinal barrier
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Micromechanics and Microengineering"
DOI: 10.1088/1361-6439/aa96bd
Abstract: In vitro modeling of organs could provide a controlled platform for studying physiological events and has great potential in the field of pharmaceutical development. Here, we describe the characterization of in vitro modeling of the… read more here.
Keywords: porous membranes; modeling human; intestinal barrier; vitro modeling ... See more keywords
Modeling Human Genetic Disorders with CRISPR Technologies in Xenopus.
Sign Up to like & getrecommendations! Published in 2021 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot106997
Abstract: Combining the power of Xenopus developmental biology with CRISPR-based technologies promises great discoveries in understanding and treating human genetic disorders. Here we provide a practical pipeline for how to go from known disease gene(s) or… read more here.
Keywords: disorders crispr; crispr technologies; modeling human; human genetic ... See more keywords
Survey on Modeling of Human‐made Articulated Objects
Sign Up to like & getrecommendations! Published in 2024 at "Computer Graphics Forum"
DOI: 10.1111/cgf.70092
Abstract: 3D modeling of articulated objects is a research problem within computer vision, graphics, and robotics. Its objective is to understand the shape and motion of the articulated components, represent the geometry and mobility of object… read more here.
Keywords: human made; survey; geometry; articulated objects ... See more keywords
Abstract A069: Microscale modeling of the human prostate bone metastatic niche
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a069
Abstract: Difficulties in modeling the human bone metastasis microenvironment (BMME) niche contribute to limitations in our understanding of the cellular interactions that promote treatment resistance in prostate cancer. To address this, we have developed a multicellular,… read more here.
Keywords: cell; bone; prostate; modeling human ... See more keywords
Modeling human migration across spatial scales in Colombia
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232702
Abstract: Human mobility, both short and long term, are important considerations in the study of numerous systems. Economic and technological advances have led to a more interconnected global community, further increasing the need for considerations of… read more here.
Keywords: modeling human; spatial scales; migration; modeling approach ... See more keywords
Computational modeling of human multisensory spatial representation by a neural architecture
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280987
Abstract: Our brain constantly combines sensory information in unitary percept to build coherent representations of the environment. Even though this process could appear smooth, integrating sensory inputs from various sensory modalities must overcome several computational issues,… read more here.
Keywords: modeling human; multisensory; architecture; computational modeling ... See more keywords
Modeling Human Cardiac Thin Filament Structures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.932333
Abstract: Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments. Tropomyosin/troponin sterically blocks myosin-binding at low-calcium concentrations but moves to expose… read more here.
Keywords: thin filament; calcium; modeling human; tropomyosin troponin ... See more keywords
Current State of Modeling Human Psychiatric Disorders Using Zebrafish
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043187
Abstract: Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological… read more here.
Keywords: human psychiatric; psychiatric disorders; modeling human; current state ... See more keywords