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   Articles with "modeling reveals" as a keyword



Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-025-60233-2

Abstract: Inflammatory bowel diseases (IBDs) are chronic disorders involving dysregulated immune responses. Despite the role of disrupted host-microbial interaction in the pathophysiology of IBD, the underlying metabolic principles are not fully understood. We densely profiled microbiome,… read more here.

Keywords: host microbiome; host; reveals multi; modeling reveals ... See more keywords

Integrative modeling reveals key chromatin and sequence signatures predicting super-enhancers

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-38979-9

Abstract: Super-enhancers (SEs) are clusters of transcriptional enhancers which control the expression of cell identity and disease-associated genes. Current studies demonstrated the role of multiple factors in SE formation; however, a systematic analysis to assess the… read more here.

Keywords: chromatin sequence; integrative modeling; reveals key; modeling reveals ... See more keywords

Robust mixture modeling reveals category-free selectivity in reward region neuronal ensembles.

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recommendations! Published in 2018 at "Journal of neurophysiology"

DOI: 10.1152/jn.00808.2017

Abstract: Classification of neurons into clusters based on their response properties is an important tool for gaining insight into neural computations. However, it remains unclear to what extent neurons fall naturally into discrete functional categories. We… read more here.

Keywords: robust mixture; task; reveals category; modeling reveals ... See more keywords
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Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms

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recommendations! Published in 2019 at "Haematologica"

DOI: 10.3324/haematol.2018.203729

Abstract: The identification of JAK-STAT pathway mutations in the majority of patients with myeloproliferative neoplasms (MPN) led to the clinical development of JAK inhibitors and resulted in the approval of ruxolitinib for MPN therapy. Despite this… read more here.

Keywords: jak inhibitor; mathematical modeling; alternative jak; modeling reveals ... See more keywords

Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26136082

Abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID are complex, multisystem conditions that pose significant challenges in healthcare. Accumulated research evidence suggests that ME/CFS and Long COVID exhibit overlapping metabolic symptoms, indicating potential shared metabolic… read more here.

Keywords: systems modeling; reveals shared; modeling reveals; cfs long ... See more keywords