PKPD Modeling and Simulations to Support Biosimilar Development of Biphasic Insulin Aspart 30
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1152
Abstract: This paper presents an analysis of data from a comparative study of biosimilarity in terms of pharmacokinetics and pharmacodynamics in healthy volunteers using a hyperinsulinemic euglycemic clamp for reference and test biphasic insulin aspart 30… read more here.
Keywords: modeling simulations; biphasic insulin; test; insulin aspart ... See more keywords
Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-018-9596-7
Abstract: Modeling and simulations were used to support body weight-based dose selection for eslicarbazepine acetate (ESL) in pediatric subjects aged 4–17 years with partial-onset seizures. A one-compartment pediatric population pharmacokinetic model with formulation-specific first-order absorption, first-order elimination,… read more here.
Keywords: selection eslicarbazepine; dose selection; support; modeling simulations ... See more keywords
Multiscale modeling and simulations of responsive polymers
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DOI: 10.1016/j.coche.2019.02.004
Abstract: Stimuli-responsive polymers can undergo structural changes with the variation of environmental conditions, namely pH, temperature, solvent, salt ionic strength, photo field, electrical field, and so on. In recent years, stimuli-responsive polymers have attracted extensive attention due to their… read more here.
Keywords: modeling simulations; simulations responsive; responsive polymers; stimuli responsive ... See more keywords
Modeling and Simulations for 2D Materials: A ReaxFF Perspective
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DOI: 10.1088/2053-1583/acd7fd
Abstract: Recent advancements in the field of two-dimensional (2D) materials have led to the discovery of a wide range of 2D materials with intriguing properties. Atomistic-scale simulation methods have played a key role in these discoveries.… read more here.
Keywords: simulations materials; modeling simulations; reaxff perspective; materials reaxff ... See more keywords
Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13233
Abstract: Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by recurrent episodes of swelling of the skin, larynx, gastrointestinal tract, genitals, and extremities that can be disruptive to patient quality of life. Dysregulation of plasma… read more here.
Keywords: plasma kallikrein; hereditary angioedema; modeling simulations; population pharmacokinetic ... See more keywords