Modeling Down syndrome in cells: From stem cells to organoids.
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DOI: 10.1016/bs.pbr.2019.10.003
Abstract: Down Syndrome (DS) is a complex chromosomal disorder, with neurological issues, featuring among the symptoms. Primary neuronal cells and tissues are extremely useful, but limited both in supply and experimental manipulability. To better understand the… read more here.
Keywords: stem cells; cells stem; cells organoids; syndrome cells ... See more keywords
Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.02.001
Abstract: Summary The brain of Down syndrome (DS) patients exhibits fewer interneurons in the cerebral cortex, but its underlying mechanism remains unknown. By morphometric analysis of cortical interneurons generated from DS and euploid induced pluripotent stem… read more here.
Keywords: gabaergic neurons; syndrome patient; ipscs reveals; migration ... See more keywords