Sharing is Caring: The Case for Company-Level Collaboration in Pharmacoeconomic Modelling
Sign Up to like & getrecommendations! Published in 2017 at "PharmacoEconomics"
DOI: 10.1007/s40273-017-0516-2
Abstract: In the recent NICE appraisals for rheumatoid arthritis the six companies involved each independently conducted systematic reviews, economic modelling and network meta-analyses [1]. Each will have incurred substantial agency fees and internal time to manage… read more here.
Keywords: company level; level collaboration; modelling; case company ... See more keywords
Generic functional modelling of multi-pulse auto-transformer rectifier units for more-electric aircraft applications
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Aeronautics"
DOI: 10.1016/j.cja.2018.03.010
Abstract: Abstract The Auto-Transformer Rectifier Unit (ATRU) is one preferred solution for high-power AC/DC power conversion in aircraft. This is mainly due to its simple structure, high reliability and reduced kVA ratings. Indeed, the ATRU has… read more here.
Keywords: aircraft; transformer rectifier; modelling; electric aircraft ... See more keywords
Computational modelling of potentially emerging SARS-CoV-2 spike protein RBDs mutations with higher binding affinity towards ACE2: A structural modelling study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.105163
Abstract: The spike protein of SARS-CoV-2 and the host ACE2 receptor plays a vital role in the entry to the cell. Among which the hotspot residue 501 is continuously subjected to positive selection pressure and induces… read more here.
Keywords: potentially emerging; sars cov; spike protein; binding affinity ... See more keywords
Soft body impact on composites: Delamination experiments and advanced numerical modelling
Sign Up to like & getrecommendations! Published in 2021 at "Composites Science and Technology"
DOI: 10.1016/j.compscitech.2021.108777
Abstract: Abstract Cohesive interface elements have become commonly used for modelling composites delamination. However, a limitation of this technique is the fine mesh size required. Here, a novel cohesive element formulation is proposed and demonstrated for… read more here.
Keywords: formulation; soft body; composites delamination; element ... See more keywords
Conceptual advancement of socio-ecological modelling of ecosystem services for re-evaluating Brownfield land
Sign Up to like & getrecommendations! Published in 2018 at "Ecosystem services"
DOI: 10.1016/j.ecoser.2018.08.003
Abstract: Essential environmental resources are rapidly exploited globally, while social-ecological systems at different scales fail to meet sustainable development challenges. Ecosystem services research, which at present predominantly utilizes static modelling approaches, needs better integration with socio-economic… read more here.
Keywords: modelling; ecosystem; conceptual advancement; ecosystem services ... See more keywords
Numerical modelling of reinforced concrete frames with masonry infills and rubber joints
Sign Up to like & getrecommendations! Published in 2021 at "Engineering Structures"
DOI: 10.1016/j.engstruct.2021.112833
Abstract: Masonry infill walls are critical components of reinforced concrete (RC) frames, which may be damaged even under earthquake events of moderate intensity, thus resulting in significant losses. Recent experimental and numerical studies have investigated innovative… read more here.
Keywords: infill walls; concrete frames; modelling; reinforced concrete ... See more keywords
An investigation into the development of toppling at the edge of fractured rock plateaux using a numerical modelling approach
Sign Up to like & getrecommendations! Published in 2017 at "Geomorphology"
DOI: 10.1016/j.geomorph.2017.03.023
Abstract: Abstract The mechanisms controlling the onset of minor slope instability at the edges of rocky plateaux exhibiting lateral spreading phenomena are yet to be fully understood. Hypotheses have recently been introduced to explain the influence… read more here.
Keywords: investigation development; modelling; fractured rock; approach ... See more keywords
Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.05.011
Abstract: Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women. Such optimised CQ-based regimens, used as treatment… read more here.
Keywords: pregnancy; treatment; population pharmacokinetic; modelling ... See more keywords
Mathematical modelling of COVID-19: a systematic review and quality assessment in the early epidemic response phase
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.12.260
Abstract: Purpose Epidemiological models have played a key role in informing national response strategies for the current COVID-19 pandemic. We aimed to identify how mathematical models were employed in the early phase of the pandemic, at… read more here.
Keywords: mathematical modelling; systematic review; uncertainty; modelling ... See more keywords
Buildings environmental impacts' sensitivity related to LCA modelling choices of construction materials
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cleaner Production"
DOI: 10.1016/j.jclepro.2017.04.052
Abstract: Abstract The assessment of the environmental performance of buildings is now commonly using a life cycle approach, based on a growing number of databases and methods in Life Cycle Assessment (LCA). Recent studies have, however,… read more here.
Keywords: different modelling; sensitivity; modelling; construction materials ... See more keywords
Improved dynamical modelling of freely falling underwater cylinder based on CFD
Sign Up to like & getrecommendations! Published in 2020 at "Ocean Engineering"
DOI: 10.1016/j.oceaneng.2020.107538
Abstract: Abstract An improved dynamic modelling approach using CFD is proposed to study the underwater motion of a dropped cylinder. Firstly, validation studies on RANS simulated flow past two dimensional (2D) and three dimensional (3D) cylinders… read more here.
Keywords: dynamical modelling; freely falling; modelling; modelling freely ... See more keywords