Discovery of new potent lysine specific histone demythelase-1 inhibitors (LSD-1) using structure based and ligand based molecular modelling and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05102h
Abstract: Lysine-specific histone demethylase 1 (LSD-1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 and is highly overexpressed in different types of cancer. Therefore, it has been… read more here.
Keywords: specific histone; histone; machine learning; modelling machine ... See more keywords
Revisiting genome-wide association studies from statistical modelling to machine learning
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa263
Abstract: Over the last decade, genome-wide association studies (GWAS) have discovered thousands of genetic variants underlying complex human diseases and agriculturally important traits. These findings have been utilized to dissect the biological basis of diseases, to… read more here.
Keywords: genome wide; association studies; machine learning; modelling machine ... See more keywords
Microcapsule Triggering Mechanics in Cementitious Materials: A Modelling and Machine Learning Approach
Sign Up to like & getrecommendations! Published in 2024 at "Materials"
DOI: 10.3390/ma17030764
Abstract: Self-healing cementitious materials containing microcapsules filled with healing agents can autonomously seal cracks and restore structural integrity. However, optimising the microcapsule mechanical properties to survive concrete mixing whilst still rupturing at the cracked interface to… read more here.
Keywords: microcapsule; machine learning; mechanics; modelling machine ... See more keywords