Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant Glioblastoma
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DOI: 10.1038/s41598-018-25588-1
Abstract: Glioblastoma (GBM) is an aggressive and incurable tumor of the brain with limited treatment options. Current first-line standard of care is the DNA alkylating agent temozolomide (TMZ), but this treatment strategy adds only ~4 months… read more here.
Keywords: glioblastoma; tmz resistance; proliferation; resistance ... See more keywords
Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome
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DOI: 10.3389/fphys.2020.624129
Abstract: Long-QT Syndrome (LQTS) is a cardiac electrical disorder, distinguished by irregular heart rates and sudden death. Accounting for ∼40% of cases, LQTS Type 2 (LQTS2), is caused by defects in the Kv11.1 (hERG) potassium channel… read more here.
Keywords: long syndrome; inherited lqts2; models acquired; acquired inherited ... See more keywords