Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47452-6
Abstract: Acute stress facilitates long-term potentiation (LTP) in the mouse hippocampus by modulating glucocorticoid receptors and ion channels. Here, we analysed whether this occurs in mouse models of Alzheimer’s disease (AD) with impaired LTP induction. We… read more here.
Keywords: mouse models; alzheimer disease; impaired ltp; stress ... See more keywords
Amyloid‐β oligomers in cellular models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15030
Abstract: Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to plaque formation, Aβ aggregates into non‐fibrillar soluble oligomers… read more here.
Keywords: alzheimer disease; cellular models; oligomers cellular; amyloid oligomers ... See more keywords
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-018-0283-3
Abstract: BackgroundNeuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ influx and aberrant neuronal activity, which accelerates neurodegeneration… read more here.
Keywords: rap1 signalling; alzheimer disease; disease; ca2 ... See more keywords
Mouse Models of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.912995
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, eventually leading to dementia. The pathological hallmarks of AD are senile plaques and neurofibrillary tangles, which comprise abnormally aggregated β-amyloid peptide… read more here.
Keywords: models alzheimer; alzheimer disease; mouse models; mouse ... See more keywords
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105404
Abstract: Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP)… read more here.
Keywords: disease; alzheimer disease; transgenic mouse; models alzheimer ... See more keywords