Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-017-9374-y
Abstract: Breast tumor heterogeneity has been well documented through the use of multiplatform –omic studies in human tumors. However, there is no integrative database to capture the heterogeneity within mouse models of breast cancer. This project… read more here.
Keywords: cancer; mouse models; models breast; breast cancer ... See more keywords
Hallmarks and Determinants of Oncogenic Translation Revealed by Ribosome Profiling in Models of Breast Cancer☆
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.12.002
Abstract: Gene expression is extensively and dynamically modulated at the level of translation. How cancer cells prioritize the translation of certain mRNAs over others from a pool of competing mRNAs remains an open question. Here, we… read more here.
Keywords: ribosome profiling; oncogenic translation; breast cancer; models breast ... See more keywords
Abstract 1017: Vinorelbine, cyclophosphamide, and 5-FU effects on the circulating and intratumoral landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1017
Abstract: Checkpoint inhibitors (CIs) are active in many types of cancer. However, only a minority of patients achieve complete and/or long-lasting responses. We studied the effects of 4 different doses of 3 widely-used, orally-active chemotherapeutics (vinorelbine,… read more here.
Keywords: vinorelbine cyclophosphamide; landscape; effects circulating; models breast ... See more keywords
Abstract 5691: Evaluation of immunomodulatory agents in classically immunologically 'cold' cancers using syngeneic mouse models of breast and ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5691
Abstract: The clinical successes of immunotherapy in immunologically “hot” cancers such as kidney, bladder and lung cancers has lead researchers to pursue strategies to improve the initiation of immune responses in immunologically more “cold” cancers such… read more here.
Keywords: syngeneic mouse; breast ovarian; models breast; ovarian cancer ... See more keywords
Abstract ES10-1: Genetic dissection of cancer development, therapy response, and resistance in mouse models of breast cancer
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DOI: 10.1158/1538-7445.sabcs17-es10-1
Abstract: Genetically engineered mouse models (GEMMs) and patient-derived xenograft (PDX) models of breast cancer have proven invaluable for basic and translational cancer research. These preclinical models have been useful for in vivo analysis of breast cancer… read more here.
Keywords: cancer; mouse models; models breast; breast cancer ... See more keywords
Large Animal Models of Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.788038
Abstract: In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and feline subjects, more… read more here.
Keywords: animal models; breast cancer; models breast; large animal ... See more keywords