Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.08.002
Abstract: Neuronal injury within specific brain regions is considered a critical risk factor in the pathophysiology of depression. However, the underlying mechanisms of this process, and thus the potential for development of novel therapeutic strategies in… read more here.
Keywords: depression; interleukin role; models depression; like behaviors ... See more keywords
Stress Models of Depression: A Question of Bad Timing
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0045-17.2017
Abstract: Current antidepressant pharmacotherapy remains unsatisfactory because of its limited adherence and partial therapeutic efficacy. Accordingly, there is a crucial need of validated animal models that fully reflect the nature of the disease and do not… read more here.
Keywords: depression; depression question; stress models; models depression ... See more keywords
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s351421
Abstract: Background There is growing evidence to suggest that ginsenoside Rd (GRd) has a therapeutic effect on depression, but the specific mechanisms behind its activity require further study. Objective This study is designed to investigate the… read more here.
Keywords: antidepressant like; effect; hif; like effect ... See more keywords
AI Machine Learning Technique Characterizes Potential Markers of Depression in Two Animal Models of Depression
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13050763
Abstract: (1) Background: there is an urgent clinical need for rapid and effective antidepressants. (2) Methods: We employed proteomics to profile proteins in two animal models (n = 48) of Chronic Unpredictable Stress and Chronic Social… read more here.
Keywords: animal models; two animal; depression; machine learning ... See more keywords
Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113543
Abstract: Antidepressants (ADs) are, for now, the best everyday treatment we have for moderate to severe major depressive episodes (MDEs). ADs are among the most prescribed drugs in the Western Hemisphere; however, the trial-and-error prescription strategy… read more here.
Keywords: transcriptomic studies; meta analysis; action; models depression ... See more keywords