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   Articles with "models drug" as a keyword



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In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation

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recommendations! Published in 2022 at "Drug Metabolism Reviews"

DOI: 10.1080/03602532.2022.2064487

Abstract: Abstract Drug-induced liver injury (DILI) is one of the major causes of post-approval withdrawal of therapeutics. As a result, there is an increasing need for accurate predictive in vitro assays that reliably detect hepatotoxic drug… read more here.

Keywords: drug induced; hepatotoxicity screening; vitro cell; models drug ... See more keywords
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eModel-BDB: a database of comparative structure models of drug-target interactions from the Binding Database

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recommendations! Published in 2018 at "GigaScience"

DOI: 10.1093/gigascience/giy091

Abstract: ABSTRACT Background The structural information on proteins in their ligand-bound conformational state is invaluable for protein function studies and rational drug design. Compared to the number of available sequences, not only is the repertoire of… read more here.

Keywords: protein; emodel bdb; models drug; drug ... See more keywords
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The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction

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recommendations! Published in 2020 at "Journal of Psychopharmacology"

DOI: 10.1177/0269881120944159

Abstract: Background: Exposure to drugs of abuse induces neuroadaptations in critical nodes of the so-called reward systems that are thought to mediate the transition from controlled drug use to the compulsive drug-seeking that characterizes addictive disorders.… read more here.

Keywords: mtor pathway; models drug; drug; mtor ... See more keywords
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Animal models of drug addiction.

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recommendations! Published in 2017 at "Adicciones"

DOI: 10.20882/adicciones.862

Abstract: The development of animal models of drug reward and addiction is an essential factor for progress in understanding the biological basis of this disorder and for the identification of new therapeutic targets. Depending on the… read more here.

Keywords: addiction; models drug; drug; reward ... See more keywords
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Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook

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recommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2021.658941

Abstract: 1 Laboratory for Biological Characterisation of Advanced Materials (LBCAM), Department of Clinical Medicine, Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland, 2 Advanced Materials and BioEngineering Research (AMBER) Centre, Centre for Research on Adaptive… read more here.

Keywords: medicine; editorial use; drug development; dublin ... See more keywords