Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma
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DOI: 10.1016/j.tranon.2022.101368
Abstract: Highlights • A novel pair of orthotopic PDX models of glioma bearing IDH1-R132H/R132C mutations.• New mutant IDH1i (SY-435) with standard therapy led to strong therapeutic efficacy.• H3K4/K9 methylation/mtDNA-encoded molecules mediate anti-tumor activity of SYC-435.• Discovered… read more here.
Keywords: 435 standard; syc 435; models glioma; standard therapy ... See more keywords
Large Animal Models of Glioma: Current Status and Future Prospects
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DOI: 10.21873/anticanres.15347
Abstract: Enhanced understanding of the molecular features of glioma has led to an expansion of murine glioma models and successful preclinical studies. However, clinical trials continue to have a high cost, extended production time, and low… read more here.
Keywords: large animal; models glioma; animal models; current status ... See more keywords