PAC-FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures.
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DOI: 10.1111/epi.18592
Abstract: Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.… read more here.
Keywords: predictive validity; models highest; validity; focal onset ... See more keywords