Towards 3D-bioprinted Models of the Liver to Boost Drug Development.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200264
Abstract: The main problems in drug development are connected to enormous costs related to the paltry success rate. The current situation empowered the development of high-throughput and reliable instruments, in addition to the current golden standards,… read more here.
Keywords: development; bioprinted models; models liver; drug development ... See more keywords
Orthotopic Pancreatic Tumor Mouse Models of Liver Metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8879-2_27
Abstract: The survival from pancreatic cancer is poor because most patients are diagnosed after the cancer has metastasized. Liver is the most common site of pancreatic cancer metastasis. Orthotopic mouse models of liver metastasis by intrasplenically… read more here.
Keywords: pancreatic tumor; mouse models; models liver; metastasis ... See more keywords
Mouse Models of Liver Parenchyma Injuries and Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.903740
Abstract: Mice have genetic and physiological similarities with humans and a well-characterized genetic background that is easy to manipulate. Murine models have become the most favored, robust mammalian systems for experimental analyses of biological processes and… read more here.
Keywords: mouse; models liver; murine models; liver injuries ... See more keywords
An update on animal models of liver fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1160053
Abstract: The development of liver fibrosis primarily determines quality of life as well as prognosis. Animal models are often used to model and understand the underlying mechanisms of human disease. Although organoids can be used to… read more here.
Keywords: liver fibrosis; animal models; development; models liver ... See more keywords
MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169380
Abstract: MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate target mRNA expression, and altered expression of miRNAs is associated with liver pathological conditions. Recent studies in animal models have shown neutrophil/myeloid-specific microRNA-223 (miR-223) as a… read more here.
Keywords: hscs; organoid models; microrna 223; mir 223 ... See more keywords