Evaluation of simulation models to mimic the distortions introduced into squiggles by nanopore sequencers and segmentation algorithms
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DOI: 10.1371/journal.pone.0219495
Abstract: Nucleotides ratcheted through the biomolecular pores of nanopore sequencers generate raw picoamperage currents, which are segmented into step-current level signals representing the nucleotide sequence. These ‘squiggles’ are a noisy, distorted representation of the underlying true… read more here.
Keywords: simulation models; models mimic; nanopore sequencers; evaluation simulation ... See more keywords