Parkinson’s disease pathogenesis from the viewpoint of small fish models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1772-1
Abstract: Parkinson’s disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have… read more here.
Keywords: models parkinson; fish models; disease pathogenesis; small fish ... See more keywords
Neuroprotective effect of olfactory ensheathing cells co‐transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.12.038
Abstract: Aims: The aim of the study is to evaluate the neuroprotective effects of olfactory ensheathing cells (OECs) with the overexpression of nuclear receptor‐related factor 1 (Nurr1) and neurogenin 2 (Ngn2) in experimental models of Parkinson's… read more here.
Keywords: models parkinson; olfactory ensheathing; nurr1 ngn2; ensheathing cells ... See more keywords
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02567-3
Abstract: L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminished sonic hedgehog (Shh) signaling in the basal… read more here.
Keywords: models parkinson; dopa; dopa induced; parkinson disease ... See more keywords
Novel models for Parkinson’s disease and their impact on future drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2018.1428556
Abstract: ABSTRACT Introduction: Parkinson’s disease is a progressive neurodegenerative disease that affects millions of elderly individuals worldwide. Despite intensive efforts dedicated to find a better treatment, the pathogenesis of Parkinson’s Disease remains unknown. In search for… read more here.
Keywords: models parkinson; treatment; disease; parkinson disease ... See more keywords
Models of Parkinson's Disease Patient Gait
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2019.2961808
Abstract: Parkinson's Disease is a disorder with diagnostic symptoms that include a change to a walking gait. The disease is problematic to diagnose. An objective method of monitoring the gait of a patient is required to… read more here.
Keywords: parkinson disease; patient gait; models parkinson; disease patient ... See more keywords
Quantitative Profiling of Synuclein Species: Application to Transgenic Mouse Models of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-191835
Abstract: INTRODUCTION Improved analytical tools for detailed characterization of synucleins in pre-clinical models of Parkinson's disease (PD) and related synucleinopathies are needed. OBJECTIVE Develop a multiple reaction monitoring (MRM) liquid chromatography tandem mass spectrometry (LC-MS/MS) assay… read more here.
Keywords: application; parkinson disease; models parkinson; mouse ... See more keywords
The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-213053
Abstract: BACKGROUND Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures. OBJECTIVE… read more here.
Keywords: prosaas; models parkinson; chaperone; parkinson disease ... See more keywords
New models of Parkinson’s like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1038721
Abstract: Microglia activation and neuroinflammation have been extensively studied in murine models of neurodegenerative diseases; however, to overcome the genetic differences between species, a human cell model of microglia able to recapitulate the activation profiles described… read more here.
Keywords: models parkinson; parkinson like; like neuroinflammation; human microglia ... See more keywords