Accounting for fast vs slow exchange in single molecule FRET experiments reveals hidden conformational states
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.4c01068
Abstract: Proteins are dynamic systems whose structural preferences determine their function. Unfortunately, building atomically detailed models of protein structural ensembles remains challenging, limiting our understanding of the relationships between sequence, structure, and function. Combining single molecule… read more here.
Keywords: models protein; molecule; fast slow; accounting fast ... See more keywords
Inherent limitations of probabilistic models for protein-DNA binding specificity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005638
Abstract: The specificities of transcription factors are most commonly represented with probabilistic models. These models provide a probability for each base occurring at each position within the binding site and the positions are assumed to contribute… read more here.
Keywords: inherent limitations; protein dna; models protein; probabilistic models ... See more keywords