What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?
Sign Up to like & getrecommendations! Published in 2024 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00376
Abstract: Recent advancements in AI-driven computational modeling, especially AlphaFold2, have revolutionized the prediction of biological macromolecule structures. AlphaFold2 enabled accurate predictions of structural domains and complex arrangements. However, computational models lack a clear metric for accuracy.… read more here.
Keywords: structural models; models proteins; crystallographic resolution; resolution ... See more keywords
Mutational Paths with Sequence-Based Models of Proteins: From Sampling to Mean-Field Characterization.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review letters"
DOI: 10.1103/physrevlett.130.158402
Abstract: Identifying and characterizing mutational paths is an important issue in evolutionary biology, with potential applications to bioengineering. We here propose an algorithm to sample mutational paths, which we benchmark on exactly solvable models of proteins… read more here.
Keywords: sequence based; mutational paths; sequence; models proteins ... See more keywords