Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration
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DOI: 10.1371/journal.pone.0177224
Abstract: We have analyzed the complex pattern of the inflammatory response in early-onset canine models of human retinitis pigmentosa, rcd1, xlpra2 and erd, as well as late-onset xlpra1, in comparative manner. The time course of immune… read more here.
Keywords: canine models; early onset; response; inflammatory genes ... See more keywords
Rhodopsin-positive cell production by intravitreal injection of small molecule compounds in mouse models of retinal degeneration
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DOI: 10.1371/journal.pone.0282174
Abstract: We aimed to verify whether the intravitreal injection of small molecule compounds alone can create photoreceptor cells in mouse models of retinal degeneration. Primary cultured mouse Müller cells were stimulated in vitro with combinations of… read more here.
Keywords: intravitreal injection; retinal degeneration; rhodopsin; rhodopsin positive ... See more keywords
Cellular Mechanisms of Angiogenesis in Neonatal Rat Models of Retinal Neurodegeneration
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DOI: 10.3390/ijms20194759
Abstract: Νeuronal and glial cells play an important role in the development of vasculature in the retina. In this study, we investigated whether re-vascularization occurs in retinal neurodegenerative injury models. To induce retinal injury, N-methyl-D-aspartic acid… read more here.
Keywords: vascularization; angiogenesis neonatal; neonatal rat; retinal neurodegeneration ... See more keywords