Coalescence Models Reveal the Rise of the White-Bellied Rat (Niviventer confucianus) Following the Loss of Asian Megafauna
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mammalian Evolution"
DOI: 10.1007/s10914-018-9428-y
Abstract: Rodents are the major remaining mammals in many terrestrial ecosystems after the historical loss of megafauna and large-bodied taxa. Niviventer confucianus is a dominant habitat generalist in natural forests in most of China. It is… read more here.
Keywords: models reveal; niviventer confucianus; coalescence models; loss megafauna ... See more keywords
Neuronal population models reveal specific linear conductance controllers sufficient to rescue preclinical disease phenotypes
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103279
Abstract: Summary Preclinical drug candidates are screened for their ability to ameliorate in vitro neuronal electrophysiology, and go/no-go decisions progress drugs to clinical trials based on population means across cells and animals. However, these measures do… read more here.
Keywords: models reveal; population models; disease; drug ... See more keywords
Geometric models reveal behavioural and neural signatures of transforming experiences into memories.
Sign Up to like & getrecommendations! Published in 2021 at "Nature human behaviour"
DOI: 10.1038/s41562-021-01051-6
Abstract: How do we preserve and distort our ongoing experiences when encoding them into episodic memories? The mental contexts in which we interpret experiences are often person-specific, even when the experiences themselves are shared. Here we… read more here.
Keywords: models reveal; geometric models; reveal behavioural; neural signatures ... See more keywords
Polymer models reveal how chromatin modification can modulate force at the kinetochore
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0041
Abstract: A key feature of chromosome segregation is the ability to sense tension between sister kinetochores. DNA between sister kinetochores must be packaged in a way that sustains tension propagation from one kinetochore to its sister,… read more here.
Keywords: sister; models reveal; reveal chromatin; sister kinetochores ... See more keywords
Abstract 872: Genetic models reveal that the novelVGLL2-NCOA2fusion oncogene leverages embryonic programs for sarcomagenesis
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-872
Abstract: Rhabdomyosarcoma (RMS) is an aggressive pediatric cancer characterized by a misregulation of skeletal muscle developmental pathways. To date, identified oncogenic drivers predominantly include RAS mutations or chromosomal translocations and gene fusions between PAX3 or PAX7… read more here.
Keywords: vgll2 ncoa2; models reveal; vgll2; leverages embryonic ... See more keywords
Hidden variable models reveal the effects of infection from changes in host survival
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010910
Abstract: The impacts of disease on host vital rates can be demonstrated using longitudinal studies, but these studies can be expensive and logistically challenging. We examined the utility of hidden variable models to infer the individual… read more here.
Keywords: hidden variable; disease; models reveal; variable models ... See more keywords
Cdx2 Animal Models Reveal Developmental Origins of Cancers
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10110928
Abstract: The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in… read more here.
Keywords: models reveal; cdx2; animal models; identity ... See more keywords