Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41572-9
Abstract: Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of lactate energetically couples astrocytes and neurons and supports brain bioenergetics. We examined the concentration… read more here.
Keywords: schizophrenia; postmortem brain; lactate; animal models ... See more keywords
Treatments for Social Interaction Impairment in Animal Models of Schizophrenia: A Critical Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbac093
Abstract: BACKGROUND While pharmacological treatments for positive symptoms of schizophrenia are widely used, their beneficial effect on negative symptoms, particularly social impairment, is insufficiently studied. Therefore, there is an increasing interest in preclinical research of potentially… read more here.
Keywords: social interaction; animal models; review; models schizophrenia ... See more keywords
Update on current animal models for schizophrenia: are they still useful?
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Psychiatry"
DOI: 10.1097/yco.0000000000000854
Abstract: Purpose of review Schizophrenia is a psychiatric disorder that has a significant socioeconomic impact worldwide. Antipsychotic drugs targeting dopamine transmission alleviate psychotic symptoms but with limited efficacy and tolerability. Animal models have long proven useful… read more here.
Keywords: schizophrenia still; animal models; models schizophrenia; current animal ... See more keywords
Neurobehavioral profiles of six genetically-based rat models of schizophrenia related symptoms.
Sign Up to like & getrecommendations! Published in 2023 at "Current neuropharmacology"
DOI: 10.2174/1570159x21666230221093644
Abstract: Schizophrenia is a chronic and severe mental disorder with high heterogeneity in its symptoms clusters. The effectiveness of drug treatments for the disorder is far from satisfactory. It is widely accepted that research with valid… read more here.
Keywords: models schizophrenia; rat models; genetically based; six genetically ... See more keywords
Disorganization of Oscillatory Activity in Animal Models of Schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2021.741767
Abstract: Schizophrenia is a chronic, debilitating disorder with diverse symptomatology, including disorganized cognition and behavior. Despite considerable research effort, we have only a limited understanding of the underlying brain dysfunction. In this article, we review the… read more here.
Keywords: phase; oscillatory; activity; models schizophrenia ... See more keywords
From the Clinic to the Laboratory, and Back Again: Investigations on Cannabinoids and Endocannabinoid System Modulators for Treating Schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.682611
Abstract: The present mini-review focuses on animal models of schizophrenia that have explored the effects of cannabidiol (CBD; a non-psychoactive component of cannabis) or the pharmacological manipulation of the endocannabinoid system on behavioral and cognitive outcome… read more here.
Keywords: system; endocannabinoid system; clinic laboratory; models schizophrenia ... See more keywords
Cellular Models in Schizophrenia Research
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168518
Abstract: Schizophrenia (SZ) is a prevalent functional psychosis characterized by clinical behavioural symptoms and underlying abnormalities in brain function. Genome-wide association studies (GWAS) of schizophrenia have revealed many loci that do not directly identify processes disturbed… read more here.
Keywords: schizophrenia research; models schizophrenia; cellular models;