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   Articles with "moderate hypothermia" as a keyword



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Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial

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recommendations! Published in 2019 at "JAMA Neurology"

DOI: 10.1001/jamaneurol.2018.4822

Abstract: Importance Moderate hypothermia in addition to early decompressive hemicraniectomy has been suggested to further reduce mortality and improve functional outcome in patients with malignant middle cerebral artery (MCA) stroke. Objective To investigate whether moderate hypothermia… read more here.

Keywords: hemicraniectomy; mortality; standard care; care ... See more keywords
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Adjuvant therapeutic potential of moderate hypothermia for glioblastoma

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recommendations! Published in 2021 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-021-03704-y

Abstract: Glioblastoma is the most common malignant brain tumor, currently treated by surgery followed by concomitant radiotherapy and temozolomide-based chemotherapy. Despite these treatments, median survival is only 15 months as a result of tumor recurrence in… read more here.

Keywords: glioblastoma; hypothermia; potential moderate; cell ... See more keywords
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Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway

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recommendations! Published in 2018 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-018-1315-1

Abstract: BackgroundComplex mechanisms participate in microglial activation after a traumatic brain injury (TBI). TBI can induce autophagy and apoptosis in neurons and glial cells, and moderate hypothermia plays a protective role in the acute phase of… read more here.

Keywords: autophagy apoptosis; hypothermia; tbi; moderate hypothermia ... See more keywords
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Myocardial electrophysiological and mechanical changes caused by moderate hypothermia—A clinical study

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recommendations! Published in 2022 at "Physiological Reports"

DOI: 10.14814/phy2.15259

Abstract: Moderate hypothermia has been used to improve outcomes in comatose out‐of‐hospital cardiac arrest survivors during the past two decades, although the effects remain controversial. We have recently shown in an experimental study that myocardial electrophysiological… read more here.

Keywords: dispersion; electrophysiological mechanical; hypothermia; electromechanical window ... See more keywords
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Moderate hypothermia induces protein SUMOylation in bone marrow stromal cells and enhances their tolerance to hypoxia.

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recommendations! Published in 2017 at "Molecular medicine reports"

DOI: 10.3892/mmr.2017.7425

Abstract: Acute cerebral infarction can progress rapidly, and there are limited specific and effective treatments. Small ubiquitin‑like modifiers (SUMOs) provide an important post‑translational modification of proteins. Following cerebral infarction, multiple proteins can combine with SUMOs to… read more here.

Keywords: sumoylation; marrow stromal; hypothermia; multiple proteins ... See more keywords