Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.3023
Abstract: Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an unmet need for treatments that provide rapid and high levels of skin clearance and itch improvement. Objective To assess the safety and… read more here.
Keywords: week; safety; efficacy; upadacitinib dupilumab ... See more keywords
Bimekizumab Safety in Patients With Moderate to Severe Plaque Psoriasis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2022.1185
Abstract: Key Points Question What is the 2-year safety profile of bimekizumab in patients with moderate to severe plaque psoriasis? Findings In this cohort study including 1789 patients receiving bimekizumab, pooled data on 2 years of… read more here.
Keywords: safety; patients moderate; moderate severe; plaque psoriasis ... See more keywords
Efficacy and Safety of Difelikefalin in Japanese Patients With Moderate to Severe Pruritus Receiving Hemodialysis
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DOI: 10.1001/jamanetworkopen.2022.10339
Abstract: Key Points Question What is the recommended dose of difelikefalin, a κ-opioid receptor agonist, in Japanese patients with moderate to severe pruritus receiving hemodialysis? Findings In this phase 2 randomized clinical trial of 247 patients,… read more here.
Keywords: receiving hemodialysis; severe pruritus; safety; moderate severe ... See more keywords
Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2021.5420
Abstract: Importance Early posttraumatic seizures (EPS) that may occur following a traumatic brain injury (TBI) are associated with poorer outcomes and development of posttraumatic epilepsy (PTE). Objective To evaluate risk factors for EPS, associated morbidity and… read more here.
Keywords: early posttraumatic; posttraumatic seizures; risk factors; risk ... See more keywords
Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT
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DOI: 10.1002/advs.202201692
Abstract: Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone microstructure, besides the well‐known cartilaginous changes. Clinical computed tomography (CT) detection of quantitative 3D microstructural subchondral bone parameters is applied to monitor changes of… read more here.
Keywords: mild moderate; bone; moderate severe; bone microstructure ... See more keywords
Population Pharmacokinetics of Tralokinumab in Adult Subjects With Moderate to Severe Atopic Dermatitis
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DOI: 10.1002/cpdd.1113
Abstract: Tralokinumab is the first biologic therapy for moderate‐to‐severe atopic dermatitis (AD) that specifically neutralizes interleukin‐13 activity, a key driver of AD signs and symptoms. Tralokinumab is a human immunoglobulin G4 monoclonal antibody administered subcutaneously every… read more here.
Keywords: severe atopic; moderate severe; atopic dermatitis; exposure ... See more keywords
Persistent moderate to severe pain and long‐term cognitive decline
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DOI: 10.1002/ejp.1826
Abstract: The longitudinal association between persistent moderate to severe pain and subsequent long‐term cognitive decline remains inconclusive. read more here.
Keywords: term cognitive; persistent moderate; long term; severe pain ... See more keywords
Safety of Oral Bisphosphonates in Moderate‐to‐Severe Chronic Kidney Disease: A Binational Cohort Analysis
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DOI: 10.1002/jbmr.4235
Abstract: Bisphosphonates are the first‐line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution in chronic kidney disease (CKD) patients, primarily because of a lack of information… read more here.
Keywords: chronic kidney; safety; disease; ckd ... See more keywords
The association between periodontitis and lung function: results from NHANES 2009-2012.
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DOI: 10.1002/jper.21-0399
Abstract: BACKGROUND We aimed to explore the association between periodontitis and lung function in the United States of America. METHODS The data was based on the National Health and Nutrition Examination Survey (NHANES) 2009-2012. Periodontitis was… read more here.
Keywords: lung function; moderate severe; severe periodontitis; periodontitis ... See more keywords
Moderate‐to‐Severe Polyhydramnios
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DOI: 10.1002/jum.15970
Abstract: Society for Maternal‐fetal medicine Consult Series (#46) states “antenatal fetal surveillance is not required for mild idiopathic” polyhydramnios defined as amniotic fluid index (AFI) of 24 cm or a deepest vertical pocket (DVP) between 8 and… read more here.
Keywords: moderate severe; medicine; severe polyhydramnios;
Obstructive sleep apnea and metabolic disorders in morbidly obese adolescents.
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DOI: 10.1002/ppul.25652
Abstract: BACKGROUND Little known about the prevalence of obstructive sleep apnea (OSA) in morbid obese adolescents and the association between OSA and comorbid factors. AIM To examine the association between apnea-hypopnea index (AHI, a measure for… read more here.
Keywords: morbidly obese; obese adolescents; obstructive sleep; sleep apnea ... See more keywords