Insights into post-translational modification enzymes from RiPPs: A toolkit for applications in peptide synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2022.107908
Abstract: The increasing length and complexity of peptide drug candidates foster the development of novel strategies for their manufacture, which should include sustainable and efficient technologies. In this context, including enzymatic catalysis in the production of… read more here.
Keywords: modification enzymes; enzymes ripps; ripps toolkit; insights post ... See more keywords
Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides.
Sign Up to like & getrecommendations! Published in 2023 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuad017
Abstract: Natural bioactive peptide discovery is a challenging and time-consuming process. However, advances in synthetic biology are providing promising new avenues in peptide engineering that allow for the design and production of a large variety of… read more here.
Keywords: large variety; new nature; engineering lanthipeptides; engineering ... See more keywords
Plasticity and conditional essentiality of modification enzymes for domain V of Escherichia coli 23S ribosomal RNA
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079096.121
Abstract: Escherichia coli rRNAs are post-transcriptionally modified at 36 positions but their modification enzymes are dispensable individually for growth, bringing into question their significance. However, a major growth defect was reported for deletion of the RlmE… read more here.
Keywords: modification; conditional essentiality; escherichia coli; knockout ... See more keywords
Proteomic and Metabolomic Analyses Provide Insights into the Mechanism on Arginine Metabolism Regulated by tRNA Modification Enzymes GidA and MnmE of Streptococcus suis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.597408
Abstract: GidA and MnmE, two important tRNA modification enzymes, are contributed to the addition of the carboxymethylaminomethyl (cmnm) group onto wobble uridine of tRNA. GidA-MnmE modification pathway is evolutionarily conserved among Bacteria and Eukarya, which is… read more here.
Keywords: arginine metabolism; trna modification; modification; modification enzymes ... See more keywords
Transfer RNA Modification Enzymes with a Thiouridine Synthetase, Methyltransferase and Pseudouridine Synthase (THUMP) Domain and the Nucleosides They Produce in tRNA
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14020382
Abstract: The existence of the thiouridine synthetase, methyltransferase and pseudouridine synthase (THUMP) domain was originally predicted by a bioinformatic study. Since the prediction of the THUMP domain more than two decades ago, many tRNA modification enzymes… read more here.
Keywords: thump; modification; thump domain; thiouridine synthetase ... See more keywords