Site‐Specific Modification of Native IgGs with Flexible Drug‐Load
Sign Up to like & getrecommendations! Published in 2024 at "Chembiochem"
DOI: 10.1002/cbic.202400511
Abstract: Homogeneous, site‐specifically conjugated antibodies have shown to result in antibody‐drug conjugates (ADCs) with improved efficacy and tolerability compared to stochastically conjugated ADCs. However, precisely controlling the drug load as well as attaching multiple payload moieties… read more here.
Keywords: antibody; modification native; site; drug ... See more keywords
Modification of native fucoidan from Fucus evanescens by recombinant fucoidanase from marine bacteria Formosa algae.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.03.094
Abstract: Enzymatic depolymerization of fucoidans attracts many researchers due to the opportunity of obtaining standardized fucoidan fragments. Fucoidanase catalyzes the cleavage of fucoidan from Fucus evanescens (FeF) to form low molecular weight products (LMP) and a… read more here.
Keywords: fucus evanescens; native fucoidan; fucoidan; modification native ... See more keywords
Precision Modification of Native Antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00342
Abstract: Antibodies, particularly of the immunoglobulin G (IgG) isotype, are a group of biomolecules that are extensively used as affinity reagents for many applications in research, disease diagnostics, and therapy. Most of these applications require antibodies… read more here.
Keywords: native antibodies; precision modification; antibody; chemistry ... See more keywords