Post-synthetic modification of oligonucleotides containing 5-mono- and 5-di-fluoromethyluridines
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DOI: 10.1016/j.tet.2020.131769
Abstract: Abstract Synthesis of 2ʹ-deoxy-5-fluoromethyluridine (dUCH2F) and 2ʹ-deoxy-5-difluoromethyluridine (dUCHF2) phosphoramidites was achieved. The obtained phosphoramidites were efficiently incorporated into oligonucleotides (ONs), and their post-synthetic modification was examined. In the case of dUCH2F-containing ONs, substitution of the… read more here.
Keywords: post synthetic; modification oligonucleotides; synthetic modification; containing mono ... See more keywords