Hydrocarbon stapling modification of peptide alyteserin‐2a: Discovery of novel stapled peptide antitumor agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3401
Abstract: Alyteserin‐2a (ILGKLLSTAAGLLSNLNH2) is isolated from the skin exudates of midwife toad and has a wide range of biological applications. However, the use of alyteserin‐2a as an antitumor agent is limited due to its structural flexibility.… read more here.
Keywords: hydrocarbon stapling; antitumor; modification peptide; peptide alyteserin ... See more keywords
A Versatile Enzymatic Pathway for Modification of Peptide C‑Termini
Sign Up to like & getrecommendations! Published in 2025 at "ACS Central Science"
DOI: 10.1021/acscentsci.5c01243
Abstract: Advances in bioinformatics have enabled the discovery of unique enzymatic reactions, particularly for ribosomally synthesized and post-translationally modified peptides (RiPPs). The recently discovered daptides, peptides with their C-terminus replaced by an amine, represent one such… read more here.
Keywords: peptide termini; versatile enzymatic; termini; enzymatic pathway ... See more keywords