A facile method for monitoring solid-phase peptide synthesis and for N-terminal modification of peptides: synthesis of short peptides for imaging specific cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-019-1683-9
Abstract: A simple method for naked-eye detection of free amine groups during solid-phase peptide synthesis is reported. The technique involves base-catalyzed cyclization of 2-(2-oxo-2H-acenaphthylene-1-ylidene)-malononitrile (1) and subsequent oxidative substitution of aryl moiety by free amine group… read more here.
Keywords: terminal modification; solid phase; peptide synthesis; phase peptide ... See more keywords
Post-Assembly Modification of Peptides by Ligand-Enabled β-C(sp3)-H Arylation of Alanine at the C-Terminus: Overcoming the Inhibition Effect of Peptide Bonds.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01481
Abstract: Postassembly modification of peptides via C(sp3)-H functionalization on aliphatic side chains provides a straightforward approach to access functionalized peptides as therapeutics. However, C(sp3)-H functionalization of C-terminal residues remains underdeveloped due to the inhibition effect of… read more here.
Keywords: inhibition effect; ligand enabled; modification peptides; alanine terminus ... See more keywords