Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors.
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DOI: 10.1021/acs.jmedchem.2c01920
Abstract: The histone lysine methyltransferase NSD2 is overexpressed, translocated, or mutated in multiple types of cancers and has emerged as an attractive therapeutic target. However, the development of small-molecule NSD2 inhibitors is still in its infancy,… read more here.
Keywords: modification pharmacological; structural modification; nsd2 inhibitors; substituted quinoline ... See more keywords