C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells.
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DOI: 10.1039/d2cc05915k
Abstract: Polytheonamide B (1) is an exceptionally large peptide that forms a transmembrane ion channel. The potent cytotoxicity of 1 against MCF-7 cancer cells originates from its two ion transport functions. Compound 1 depolarizes the plasma… read more here.
Keywords: modification polytheonamide; mcf cancer; cancer cells; terminal modification ... See more keywords