motifeR: An Integrated Web Software for Identification and Visualization of Protein Posttranslational Modification Motifs
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DOI: 10.1002/pmic.201900245
Abstract: With an exponential growth in applications identifying protein post‐translational modifications via mass spectrometry, discovery and presentation of motifs surrounding those modification sites have become increasingly desirable. Despite a few tools being designed, there is still… read more here.
Keywords: modification sites; integrated web; motifer integrated; web software ... See more keywords
Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions
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DOI: 10.1038/s42003-018-0032-8
Abstract: The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress conditions to investigate the influence of protein degradation… read more here.
Keywords: chemical modification; degradation; modification sites; sites trastuzumab ... See more keywords
iRNAD: a computational tool for identifying D modification sites in RNA sequence
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DOI: 10.1093/bioinformatics/btz358
Abstract: MOTIVATION Dihydrouridine (D) is a common RNA posttranscriptional modification found in eukaryotes, bacteria and a few archaea. The modification can promote the conformational flexibility of individual nucleotide bases. And its levels are increased in cancerous… read more here.
Keywords: modification sites; rna sequence; identifying modification; sites rna ... See more keywords
Identification of D Modification Sites Using a Random Forest Model Based on Nucleotide Chemical Properties
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DOI: 10.3390/ijms23063044
Abstract: Dihydrouridine (D) is an abundant post-transcriptional modification present in transfer RNA from eukaryotes, bacteria, and archaea. D has contributed to treatments for cancerous diseases. Therefore, the precise detection of D modification sites can enable further… read more here.
Keywords: modification; identification modification; nucleotide chemical; random forest ... See more keywords
ENet-6mA: Identification of 6mA Modification Sites in Plant Genomes Using ElasticNet and Neural Networks
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DOI: 10.3390/ijms23158314
Abstract: N6-methyladenine (6mA) has been recognized as a key epigenetic alteration that affects a variety of biological activities. Precise prediction of 6mA modification sites is essential for understanding the logical consistency of biological activity. There are… read more here.
Keywords: enet 6ma; 6ma modification; plant genomes; modification sites ... See more keywords