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   Articles with "modification systems" as a keyword



DNA methylation by three Type I restriction modification systems of Escherichia coli does not influence gene regulation of the host bacterium

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recommendations! Published in 2021 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab530

Abstract: Abstract DNA methylation is a common epigenetic mark that influences transcriptional regulation, and therefore cellular phenotype, across all domains of life. In particular, both orphan methyltransferases and those from phasevariable restriction modification systems (RMSs) have… read more here.

Keywords: methylation; restriction modification; modification systems; type ... See more keywords

Lactococcal mobile genetic elements harbour a diverse phage defensome rich in restriction-modification systems

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf854

Abstract: Abstract The genomes of 43 distinct lactococcal strains were reconstructed by a combination of long- and short-read sequencing, resolving the plasmid complement and methylome of these strains. The genomes comprised 43 chromosomes of approximately 2.5… read more here.

Keywords: modification systems; restriction modification; phage defensome; phage ... See more keywords

A model for the evolution of prokaryotic DNA restriction-modification systems based upon the structural malleability of Type I restriction-modification enzymes

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky760

Abstract: Abstract Restriction Modification (RM) systems prevent the invasion of foreign genetic material into bacterial cells by restriction and protect the host's genetic material by methylation. They are therefore important in maintaining the integrity of the… read more here.

Keywords: restriction; restriction modification; modification systems; type ... See more keywords

Highly efficient CRISPR-Cas9 base editing in Bifidobacterium with bypass of restriction modification systems

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recommendations! Published in 2025 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.01985-24

Abstract: ABSTRACT Intestinal microbiota members of the Bifidobacterium genus are increasingly explored as probiotics and therapeutics. However, the paucity of genetic tools and the widespread restriction modification (RM) systems in Bifidobacterium limit our ability to genetically… read more here.

Keywords: modification systems; base editing; base; bifidobacterium ... See more keywords

DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi

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recommendations! Published in 2018 at "Journal of Bacteriology"

DOI: 10.1128/jb.00395-18

Abstract: Lyme disease is the most prevalent vector-borne disease in North America and is classified by the Centers for Disease Control and Prevention (CDC) as an emerging infectious disease with an expanding geographical area of occurrence.… read more here.

Keywords: methylation; restriction modification; modification systems; gene ... See more keywords