Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation
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DOI: 10.1093/nar/gkac1155
Abstract: Abstract During starvation, organisms modify both gene expression and metabolism to adjust to the energy stress. We previously reported that Caenorhabditis elegans lacing AMP-activated protein kinase (AMPK) exhibit transgenerational reproductive defects associated with abnormally elevated… read more here.
Keywords: h3k4me3; following starvation; modifications cause; starvation ... See more keywords