A glimpse into the modulation of post-translational modifications of human-colonizing bacteria.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2016.11.005
Abstract: Protein post-translational modifications (PTMs) are a key bacterial feature that holds the capability to modulate protein function and responses to environmental cues. Until recently, their role in the regulation of prokaryotic systems has been largely… read more here.
Keywords: modifications human; human colonizing; post translational; modulation post ... See more keywords
Visualization of chemical modifications in the human 80S ribosome structure
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24482
Abstract: Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However, their role in this phenomenon… read more here.
Keywords: 80s ribosome; modifications human; chemical modifications; structure ... See more keywords
Proteome-wide profiling and mapping of post translational modifications in human hearts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81986-y
Abstract: Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins. PTMs contribute to regulation of protein function and thereby greatly increase the functional diversity… read more here.
Keywords: human hearts; modifications human; post translational; proteome wide ... See more keywords
Piperine protects oxidative modifications in human erythrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2020-0100
Abstract: Abstract Objectives Piperine (1-piperoyl piperidine), a major alkaloid constituent of Piper nigrum L. and Piper longum L. has pleiotropic biological effects, but the mechanism(s) involved remain to be elucidated. The current study was conducted to… read more here.
Keywords: protects oxidative; modifications human; erythrocytes piperine; oxidative modifications ... See more keywords
The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030367
Abstract: Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal cells. The mechanistic understanding of the pathways involved in tumor transformation has implicated a priori predominance of epigenetic perturbations and a… read more here.
Keywords: cancers use; use natural; modifications human; human cancers ... See more keywords
Impacts of Hyperglycemia on Epigenetic Modifications in Human Gingival Fibroblasts and Gingiva in Diabetic Rats
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252010979
Abstract: Periodontal disease is considered one of the diabetic complications with high morbidity and severity. Recent studies demonstrated the involvement of the epigenome on diabetic complications. Histone modifications change chromatin architecture and gene activation. Histone modifications… read more here.
Keywords: histone modifications; diabetic rats; modifications human; impacts hyperglycemia ... See more keywords
Symmetry of Post-Translational Modifications in a Human Enzyme
Sign Up to like & getrecommendations! Published in 2022 at "Symmetry"
DOI: 10.3390/sym14020212
Abstract: Paraoxonase 2 (PON2) is a member of a small family of human lactonases. Recently, post-translational modifications (PTMs) of PON2 were highlighted, one of which involved the modulation of the enzyme activity. Furthermore, two important single… read more here.
Keywords: translational modifications; post translational; modifications human; symmetry post ... See more keywords