Quantification of mRNA cap-modifications by means of LC-QqQ-MS.
Sign Up to like & getrecommendations! Published in 2021 at "Methods"
DOI: 10.1016/j.ymeth.2021.05.018
Abstract: Enzymatic modification of the 5'-cap is a versatile approach to modulate the properties of mRNAs. Transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) or functional moieties from non-natural analogs by methyltransferases (MTases) allows for site-specific modifications… read more here.
Keywords: mrna cap; modifications means; cap modifications; quantification mrna ... See more keywords
RNA modifications as a means of self-recognition and immune protection.
Sign Up to like & getrecommendations! Published in 2025 at "Critical reviews in biochemistry and molecular biology"
DOI: 10.1080/10409238.2025.2591027
Abstract: More than 170 distinct RNA modifications have been identified, playing pivotal roles in regulating development, homeostasis, and adaptive evolution. A recent groundbreaking study in Nature revealed that glycoRNA prevents endogenous RNA from being misidentified as… read more here.
Keywords: non self; rna; rna modifications; means self ... See more keywords