mRNA Regulation by RNA Modifications.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-052521-035949
Abstract: Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth.… read more here.
Keywords: modifications mrna; regulation rna; regulation; mrna regulation ... See more keywords
Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression.
Sign Up to like & getrecommendations! Published in 2020 at "RNA"
DOI: 10.1261/rna.077099.120
Abstract: Chemical modifications enable preparation of mRNAs with augmented stability and translational activity. In this study, we explored how chemical modifications of 5',3'-phosphodiester bonds in the mRNA body and polyA tail influence the biological properties of… read more here.
Keywords: tail prevent; polya tail; modifications mrna; mrna polya ... See more keywords