Role of Structural Modifications in Peptidomimetic Compounds as Potential Antimicrobial Agents against Staphylococcus aureus and Streptococcus pyogenes: Balancing Bioavailability, Safety, and Antimicrobial Activity
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DOI: 10.1021/acsomega.5c03775
Abstract: The emergence of drug-resistant Gram-positive pathogens, particularlyStaphylococcus aureusandStreptococcus pyogenes, has driven the need for novel antimicrobial agents. This study explores 21 newly synthesized peptidomimetic analogues of cystatin C N-terminal fragment, designed to enhance bioactivity, solubility,… read more here.
Keywords: structural modifications; modifications peptidomimetic; role structural; antimicrobial agents ... See more keywords