Rapid Characterization of Insulin Modifications and Sequence Variations by Proteinase K Digestion and UHPLC-ESI-MS
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DOI: 10.1007/s13361-017-1887-5
Abstract: AbstractDiscovery of novel insulin analogs as therapeutics has remained an active area of research. Compared with native human insulin, insulin analog molecules normally incorporate either covalent modifications or amino acid sequence variations. From the drug… read more here.
Keywords: modifications sequence; insulin; sequence variations; proteinase digestion ... See more keywords