Nucleobase-modified antisense oligonucleotides containing 5-(phenyltriazol)-2′-deoxyuridine nucleotides induce exon-skipping in vitro
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DOI: 10.1039/c7ra10964d
Abstract: Chemically-modified antisense oligonucleotide-mediated exon-skipping has been validated as a therapeutic strategy for tackling several disease pathologies, particularly duchenne muscular dystrophy. To date, only sugar-modified and internucleotide linkage-modified oligonucleotide chemistries have been explored for exon-skipping applications.… read more here.
Keywords: nucleobase modified; antisense oligonucleotides; modified antisense; phenyltriazol deoxyuridine ... See more keywords
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
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DOI: 10.1158/1535-7163.mct-18-0824
Abstract: ADP-ribosylation factor-like 4c (ARL4C) is identified as a small GTP-binding protein, which is expressed by Wnt and EGF signaling and plays an important role in tubulogenesis of cultured cells and the ureters. ARL4C is little… read more here.
Keywords: chemically modified; hcc; modified antisense; cancer ... See more keywords
Phosphorothioate‑modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy.
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DOI: 10.3892/mmr.2017.6778
Abstract: Emergence of resistance, unavoidable systemic toxicity and unsatisfactory efficacy arethe main obstacles for traditional cancer therapy. Combination with phosphorothioate modified antisense oligonucleotides (PS‑ASODN) against human telomerase reverse transcriptase (hTERT) may enhance the therapeutic effect of… read more here.
Keywords: telomerase; modified antisense; cancer; cell ... See more keywords