Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b13132
Abstract: RNA or single-stranded DNA aptamers with 2'-F pyrimidines have been pursued to increase resistance to nucleases, and while it seems likely that these and other modifications, including the modification of purines, could be used to… read more here.
Keywords: modified aptamers; aptamers optimized; fluoro modified; selection fluoro ... See more keywords
Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
Sign Up to like & getrecommendations! Published in 2018 at "Nature methods"
DOI: 10.1038/s41592-018-0105-0
Abstract: Although current implementations of super-resolution microscopy are technically approaching true molecular-scale resolution, this has not translated to imaging of biological specimens, because of the large size of conventional affinity reagents. Here we introduce slow off-rate… read more here.
Keywords: resolution; modified aptamers; dna paint; microscopy ... See more keywords