Modified cells as potential ocular drug delivery systems.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.12.004
Abstract: Drug delivery to ocular targets is problematic, especially in retinal disease treatment. Therefore, targeted drug delivery, prolonged drug action, and minimally invasive treatments are needed. In this review, we describe cell technologies for drug delivery.… read more here.
Keywords: drug delivery; delivery; modified cells; cells potential ... See more keywords
Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.08.018
Abstract: Adoptive immunotherapy adopting chimeric antigen receptor (CAR) modified T cells has arisen attention as a hard-hitting therapy for numerous cancers. CARs are genetically engineered receptors that could stimulate tumor cytotoxicity once binding to the specific… read more here.
Keywords: chimeric antigen; modified cells; receptor car; antigen receptor ... See more keywords
T-cell receptor gene-modified cells: past promises, present methodologies and future challenges.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2018.12.002
Abstract: Immunotherapy constitutes an exciting and rapidly evolving field, and the demonstration that genetically modified T-cell receptors (TCRs) can be used to produce T-lymphocyte populations of desired specificity offers new opportunities for antigen-specific T-cell therapy. Overall,… read more here.
Keywords: gene modified; modified cells; cell receptor; receptor gene ... See more keywords
Towards ‘off-the-shelf’ genetically modified T cells: prolonging functional engraftment in mice by CD8 veto T cells
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.332
Abstract: Towards ‘off-the-shelf’ genetically modified T cells: prolonging functional engraftment in mice by CD8 veto T cells read more here.
Keywords: prolonging functional; towards shelf; modified cells; cells prolonging ... See more keywords
Preclinical Evaluation of Chimeric Antigen Receptor-Modified T Cells Specific to Epithelial Cell Adhesion Molecule for Treating Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2019.178
Abstract: This is an erratum of the published paper "Preclinical Evaluation of Chimeric Antigen Receptor-Modified T Cells Specific to Epithelial Cell Adhesion Molecule for Treating Colorectal Cancer". There are some errors in figure 6C and 7C… read more here.
Keywords: preclinical evaluation; modified cells; receptor modified; antigen receptor ... See more keywords
ATIM-22. PHASE I TRIAL OF DRUG RESISTANT IMMUNOTHERAPY: A FIRST-IN-CLASS COMBINATION OF MGMT-MODIFIEDγδ T CELLS AND TEMOZOLOMIDE CHEMOTHERAPY IN NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.021
Abstract: Alkylating agents such as Temozolomide (TMZ) significantly upregulate stress-induced NKG2D ligands targeted by innate immune effector cells. Genetic modification of γδT cells with an MGMT-expressing lentivector abrogates TMZ-induced lymphodepletion allowing simultaneous chemotherapy and γδT cell… read more here.
Keywords: resistant immunotherapy; drug resistant; modified cells; chemotherapy ... See more keywords
Modified T Cells Home to Brain Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2018-125
Abstract: In a recent study, researchers investigated why brain cancers are impervious to T cells, and used their findings to create reengineered T cells that are better able to move into tumors. Their "homing system" could… read more here.
Keywords: modified cells; home brain; cells home; brain ... See more keywords
Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Current Pharmaceutical Design"
DOI: 10.2174/1381612823666170316125402
Abstract: Glioblastoma (GBM) is one of the most devastating brain tumors with poor prognosis and high mortality. Although radical surgical treatment with subsequent radiation and chemotherapy can improve the survival, the efficacy of such regimens is… read more here.
Keywords: cell therapy; adoptive cell; modified cells; receptor ... See more keywords