A high affinity modified DNA aptamer containing base-appended bases for human β-defensin.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113627
Abstract: We used base-appended base modification to develop a new adenine analog, which incorporates an adenine derivative at position 7 of adenine. Using the systematic evolution of ligands by exponential enrichment method with a modified DNA… read more here.
Keywords: high affinity; base; human defensin; base appended ... See more keywords
Magnetic studies of Co 2+ , Ni 2+ , and Zn 2+ -modified DNA double-crossover lattices
Sign Up to like & getrecommendations! Published in 2018 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2017.08.069
Abstract: Abstract We fabricated divalent-metal-ion-modified DNA double-crossover (DX) lattices on a glass substrate and studied their magnetic characteristics as a function of ion concentrations [Co 2+ ], [Ni 2+ ] and [Zn 2+ ]. Up to… read more here.
Keywords: dna lattices; dna; dna double; double crossover ... See more keywords
Natural, modified DNA bases.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.01.014
Abstract: The four canonical bases that make up genomic DNA are subject to a variety of chemical modifications in living systems. Recent years have witnessed the discovery of various new modified bases and of the enzymes… read more here.
Keywords: medicine; methodology; dna; dna bases ... See more keywords
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00760
Abstract: The mature forms of the TGF-β family members GDF-11 and GDF-8 are highly similar 25 kDa homodimers with 90% amino acid sequence identity and 99% similarity. Cross-reactivity of GDF-11 and GDF-8 binding reagents is common… read more here.
Keywords: affinity; selection; gdf; gdf gdf ... See more keywords
Design of Uracil-Modified DNA Nanotubes for Targeted Drug Release via DNA-Modifying Enzyme Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c09488
Abstract: DNA nanostructure-based responsive drug delivery has become an increasingly potent method in cancer therapy. However, a variety of important cancer biomarkers have not been explored in searching of new and efficient targeted delivery systems. Uracil… read more here.
Keywords: dna; uracil modified; dna nanotubes; drug release ... See more keywords
Recovery of Information Stored in Modified DNA with an Evolved Polymerase.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00575
Abstract: DNA is increasingly being explored as an alternative medium for digital information storage, but the potential information loss from degradation and associated issues with error during reading challenge its wide-scale implementation. To address this, we… read more here.
Keywords: dna; information; recovery information; information stored ... See more keywords
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00864-2
Abstract: IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its… read more here.
Keywords: inhibits signaling; aptamer specifically; structure; dna aptamer ... See more keywords
Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1922400117
Abstract: Significance Life on Earth depends on polymerases. These enzymes copy genetic information to produce the DNA and RNA strands at the core of the central dogma. Polymerases act by forming phosphodiester linkages to produce polynucleotide… read more here.
Keywords: dna; dna polymerase; activity; polymerase ... See more keywords
Probing the Effect of Bulky Lesion-Induced Replication Fork Conformational Heterogeneity Using 4-Aminobiphenyl-Modified DNA
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24081566
Abstract: Bulky organic carcinogens are activated in vivo and subsequently react with nucleobases of cellular DNA to produce adducts. Some of these DNA adducts exist in multiple conformations that are slowly interconverted to one another. Different… read more here.
Keywords: replication fork; bulky; inhibition; replication ... See more keywords
Enzymatic Synthesis of Vancomycin-Modified DNA
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27248927
Abstract: Many potent antibiotics fail to treat bacterial infections due to emergence of drug-resistant strains. This surge of antimicrobial resistance (AMR) calls in for the development of alternative strategies and methods for the development of drugs… read more here.
Keywords: synthesis vancomycin; synthesis; enzymatic synthesis; vancomycin modified ... See more keywords