Halogenated derivatives of methotrexate as human dihydrofolate reductase inhibitors in cancer chemotherapy
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DOI: 10.1080/07391102.2019.1591302
Abstract: Abstract Methotrexate is a widely used anti-metabolite in cancer chemotherapy. A series of halogenated drugs is designed from Methotrexate to assess their interactions with human dihydrofolate reductase. The aim of this study is to evaluate… read more here.
Keywords: modified drugs; molecular dynamics; dihydrofolate reductase; cancer chemotherapy ... See more keywords