Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
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DOI: 10.1021/acsmedchemlett.7b00256
Abstract: A series of N1-modified imidazoquinolines were synthesized and screened for Toll-like receptors (TLR) 7 and 8 activities to identify recognition elements that confer high affinity binding and selectivity. These receptors are key targets in the… read more here.
Keywords: toll like; design synthesis; modified imidazoquinoline; like receptors ... See more keywords