Modified mRNA Vaccines Protect against Zika Virus Infection
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.03.016
Abstract: (Cell 168, 742–742.e1; February 9, 2017) In the originally published version of the SnapShot, the unit of measure in the top left box of the image was incorrect. The correct unit is 1 CTC per… read more here.
Keywords: modified mrna; mrna vaccines; protect zika; zika virus ... See more keywords
Synthesis of point-modified mRNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac719
Abstract: Abstract Synthetic mRNA has recently moved into the focus of therapeutic and vaccination efforts. Incorporation of modified nucleotides during in vitro transcription can improve translation and attenuate immunogenicity, but is limited to triphosphate nucleotides which… read more here.
Keywords: point modified; incorporation; modified mrna; synthesis point ... See more keywords
CAR T cells produced in vivo to treat cardiac injury
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm0594
Abstract: Description Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al. designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR)… read more here.
Keywords: car; heart; modified mrna; cells vivo ... See more keywords
Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01723-22
Abstract: This study shows that the nucleoside-modified mRNA-LNP vaccine platform is a promising alternative for egg-based influenza vaccines. We show that mRNA-LNP vaccines expressing H3 antigens elicit high levels of antibodies in mice and protect against… read more here.
Keywords: egg; nucleoside modified; egg based; modified mrna ... See more keywords
Delivery of a Modified mRNA Encoding IL-22 Binding Protein (IL-22BP) for Colon Cancer Gene Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2018.2577
Abstract: As an alternative form of genetic material, mRNA lacks a CpG island and can function without crossing the nuclear membrane. These properties make mRNA less of a potential immune stimulant than plasmid DNA. Therefore, chemically… read more here.
Keywords: plasmid dna; gene therapy; modified mrna; mrna ... See more keywords
Modified mRNA-Based Vaccines Against Coronavirus Disease 2019
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221090259
Abstract: The pandemic of coronavirus disease 2019 (COVID-19) continuously causes deaths worldwide, representing a considerable challenge to health care and economic systems with a new precedent in human history. Many therapeutic medicines primarily focused on preventing… read more here.
Keywords: modrna vaccines; coronavirus disease; mrna based; modified mrna ... See more keywords
Application of Modified mRNA in Somatic Reprogramming to Pluripotency and Directed Conversion of Cell Fate
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158148
Abstract: Modified mRNA (modRNA)-based somatic reprogramming is an effective and safe approach that overcomes the genomic mutation risk caused by viral integrative methods. It has improved the disadvantages of conventional mRNA and has better stability and… read more here.
Keywords: stem cells; somatic reprogramming; modified mrna; application modified ... See more keywords
Modified mRNA as a Treatment for Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054737
Abstract: Myocardial infarction (MI) is a severe disease with high mortality worldwide. However, regenerative approaches remain limited and with poor efficacy. The major difficulty during MI is the substantial loss of cardiomyocytes (CMs) with limited capacity… read more here.
Keywords: therapy; myocardial infarction; modified mrna; modrna based ... See more keywords
Overcoming analytical challenges to generate data critical to understanding lipid nanoparticle-delivered modified mRNA biodistribution.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0138
Abstract: Aim: Chemically modified mRNA offers a novel approach to treat disease. Due to susceptibility to extracellular nucleases in vivo, dosed modified mRNA therapeutics can benefit from encapsulation within novel delivery systems, such as lipid nanoparticles… read more here.
Keywords: biodistribution; modified mrna; overcoming analytical; analytical challenges ... See more keywords