The Profile and Dynamics of RNA Modifications in Animals
Sign Up to like & getrecommendations! Published in 2017 at "Chembiochem"
DOI: 10.1002/cbic.201700093
Abstract: More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular and environmental stress. Mass‐spectrometry‐based methods… read more here.
Keywords: modified nucleosides; dynamics rna; modifications animals; profile dynamics ... See more keywords
Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases
Sign Up to like & getrecommendations! Published in 2019 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2018.12.004
Abstract: Abstract Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chemical synthesis of these Se-containing nucleosides is labor-intensive… read more here.
Keywords: modified nucleosides; biocatalytic synthesis; synthesis; thermostable nucleoside ... See more keywords
BH+/MH+-matching method for discovery of cis-diol-containing modified nucleosides in urine by ribose-targeted solid phase extraction followed by dual-mass spectrometry platform identification.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114555
Abstract: Profiling of new modified nucleosides from urine plays an important role in exploring biomarkers for cancer. However, limitations from the nature of the compound, bio-sample, instrumentation, and analytical method pose great challenges to achieving a… read more here.
Keywords: diol; nucleosides urine; modified nucleosides; diol containing ... See more keywords
4'-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00697
Abstract: ConspectusModified nucleosides show therapeutic promise for antiviral therapies. However, issues including the emergence of drug resistance, toxicity, and coinfections have posed new challenges for nucleoside-based antiviral drug discovery, particularly in the era of the coronavirus… read more here.
Keywords: drug discovery; antiviral drug; modified nucleosides; drug ... See more keywords
Biocatalyst CAL-B catalyzed synthesis of modified nucleosides: An overview
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1554745
Abstract: Abstract Nucleosides are valuable biologically active compounds, which display antitumour and antiviral activities. Various types of bioactive nucleosides are designed to improve their therapeutic efficacy, However this strategy faces the difficult selectivity issues of nucleoside… read more here.
Keywords: modified nucleosides; cal catalyzed; catalyzed synthesis; biocatalyst cal ... See more keywords
Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication.
Sign Up to like & getrecommendations! Published in 2021 at "RNA biology"
DOI: 10.1080/15476286.2021.1960689
Abstract: RNA contains a wide variety of posttranscriptional modifications covalently attached to its base or sugar group. These modified nucleosides are liberated from RNA molecules as the consequence of RNA catabolism and released into extracellular space,… read more here.
Keywords: export; rna derived; modified nucleosides; autophagy response ... See more keywords
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.2139/ssrn.4401797
Abstract: The plethora of viral outbreaks experienced in the last decade, together with the widespread distribution of many re-emerging and newly emerging viruses, emphasize the urgent need for novel broad-spectrum antivirals as tools for early intervention… read more here.
Keywords: spectrum antimicrobial; diaminopurine antivirals; modified nucleosides; base modified ... See more keywords
Nucleobase-modified nucleosides and nucleotides: Applications in biochemistry, synthetic biology, and drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1051525
Abstract: Abstract. DNA is often referred to as the “molecule of life” since it contains the genetic blueprint for all forms of life on this planet. The core building blocks composing DNA are deoxynucleotides. While the… read more here.
Keywords: dna; biology; nucleobase modified; modified nucleosides ... See more keywords
LC-MS/MS Determination of Modified Nucleosides in The Urine of Parkinson’s Disease and Parkinsonian Syndromes Patients
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25214959
Abstract: Epigenetic modifications play a key role in gene regulation and expression and are involved in numerous cellular processes. Due to the limited research on nucleosides in Parkinson’s disease (PD), it is very important to consider… read more here.
Keywords: parkinsonian syndromes; determination modified; modified nucleosides; parkinson disease ... See more keywords
Ultrasensitive Simultaneous Detection of Multiple Rare Modified Nucleosides as Promising Biomarkers in Low-Put Breast Cancer DNA Samples for Clinical Multi-Dimensional Diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27207041
Abstract: Early cancer diagnosis is essential for successful treatment and prognosis, and modified nucleosides have attracted widespread attention as a promising group of cancer biomarkers. However, analyzing these modified nucleosides with an extremely low abundance is… read more here.
Keywords: diagnosis; breast cancer; modified nucleosides; simultaneous detection ... See more keywords
Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27238379
Abstract: Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides,… read more here.
Keywords: nucleotides nucleic; tellurium; potential applications; nucleosides nucleotides ... See more keywords