Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.7b00173
Abstract: Members of the nucleoside analogue class of cancer therapeutics compete with canonical nucleotides to disrupt numerous cellular processes, including nucleotide homeostasis, DNA and RNA synthesis, and nucleotide metabolism. Nucleoside analogues are triphosphorylated and subsequently inserted… read more here.
Keywords: structures dna; dna; dna polymerase; modified nucleotides ... See more keywords
Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a032201
Abstract: SUMMARYAn important mechanism of gene expression regulation is the regulated modification of nucleotides in messenger RNA (mRNA). These modified nucleotides affect mRNA translation, stability, splicing, and other processes. A cluster of nucleotide modifications is found… read more here.
Keywords: mrna; modified nucleotides; comprise epitranscriptome; mapping modified ... See more keywords