Conformational Flexibility of Ubiquitin-Modified and SUMO-Modified PCNA Shown by Full-Ensemble Hybrid Methods.
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DOI: 10.1016/j.jmb.2018.10.017
Abstract: Ubiquitin-modified proliferating cell nuclear antigen (PCNA) and small ubiquitin-like modifier (SUMO)-modified PCNA regulate DNA damage tolerance pathways. X-ray crystal structures of these proteins suggested that they do not have much conformational flexibility because the modifiers… read more here.
Keywords: ensemble hybrid; flexibility; modified pcna; sumo modified ... See more keywords