Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000176
Abstract: Proteasomal spliced peptides (PSPs) have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel neoantigens that can stimulate highly specific T cells. Much debate has… read more here.
Keywords: identification spliced; modified peptides; peptides pancreatic; spliced peptides ... See more keywords
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03759-0
Abstract: The emergence and re-emergence of viral epidemics and the risks of antiviral drug resistance are a serious threat to global public health. New options to supplement or replace currently used drugs for antiviral therapy are… read more here.
Keywords: translationally modified; ripps; post translationally; ribosomally synthesized ... See more keywords
Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c03300
Abstract: Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-based approaches use solid sorbents such as streptavidin beads to… read more here.
Keywords: gas phase; modified peptides; protein profiling; protein ... See more keywords
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.2c00210
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data and recognition that they are made by biosynthetic pathways… read more here.
Keywords: ribosomally synthesized; modified peptides; translationally modified; post translationally ... See more keywords
Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c12559
Abstract: Inhibiting the fibrotic aggregation of the human islet amyloid polypeptide (hIAPP) and accelerating aggregate clearance are crucial factors in type II diabetes regulation. Autophagy plays a central role in hIAPP fibrotic degradation. We investigated how… read more here.
Keywords: seed; hiapp aggregation; modified peptides; aggregation ... See more keywords
Synthesis of Ribosomally Synthesized and Post-Translationally Modified Peptides Containing C-C Cross-Links.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00508
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are known for their macrocyclic structures, which impart unique biological activity. One rapidly emerging subclass of RiPP natural products contains macrocyclic C-C cross-links between two amino acid side… read more here.
Keywords: cross links; ribosomally synthesized; modified peptides; translationally modified ... See more keywords
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b01519
Abstract: Recently developed bioinformatic tools have bolstered the discovery of ribosomally synthesized and post-translationally modified peptides (RiPPs). Using an improved version of Rapid ORF Description and Evaluation Online (RODEO 2.0), a biosynthetic gene cluster mining algorithm,… read more here.
Keywords: translationally modified; post translationally; thioether; ribosomally synthesized ... See more keywords
Synthesis of Side-Chain Modified Peptides Using Iterative Solid Phase ‘Click’ Methodology
Sign Up to like & getrecommendations! Published in 2017 at "Australian Journal of Chemistry"
DOI: 10.1071/ch16567
Abstract: A series of side-chain modified peptides have been prepared via an iterative sequence of peptide couplings and azide–alkyne cycloadditions (‘click’ reactions) using Fmoc-solid phase peptide synthesis. This efficient modular synthetic route allows the systematic and… read more here.
Keywords: chain modified; methodology; side chain; modified peptides ... See more keywords
How to build machine learning models able to extrapolate from standard to modified peptides.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of cheminformatics"
DOI: 10.1186/s13321-025-01115-z
Abstract: Bioactive peptides are an important class of natural products with great functional versatility. Chemical modifications can improve their pharmacology, yet their structural diversity presents unique challenges for computational modeling. Furthermore, data for standard peptides (composed… read more here.
Keywords: modified peptides; build machine; standard; machine learning ... See more keywords
Autoantibodies to Oxidatively Modified Peptide: Potential Clinical Application in Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12102269
Abstract: Coronary artery disease (CAD) is a global health issue. Lipid peroxidation produces various by-products that associate with CAD, such as 4-hydroxynonenal (HNE) and malondialdehyde (MDA). The autoantibodies against HNE and MDA-modified peptides may be useful… read more here.
Keywords: coronary artery; autoantibodies oxidatively; artery disease; modified peptides ... See more keywords
Theoretical Investigation of the Material Usage During On-Bead Enrichment of Post-Translationally Modified Peptides in Suspension Systems
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30153245
Abstract: Over the past decade, the number and diversity of identified protein post-translational modifications (PTMs) have grown significantly. However, most PTMs occur at relatively low abundance, making selective enrichment of modified peptides essential. To address this,… read more here.
Keywords: modified peptides; post; theoretical investigation; enrichment ... See more keywords