Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000176
Abstract: Proteasomal spliced peptides (PSPs) have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel neoantigens that can stimulate highly specific T cells. Much debate has… read more here.
Keywords: identification spliced; modified peptides; peptides pancreatic; spliced peptides ... See more keywords
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03759-0
Abstract: The emergence and re-emergence of viral epidemics and the risks of antiviral drug resistance are a serious threat to global public health. New options to supplement or replace currently used drugs for antiviral therapy are… read more here.
Keywords: translationally modified; ripps; post translationally; ribosomally synthesized ... See more keywords
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.2c00210
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data and recognition that they are made by biosynthetic pathways… read more here.
Keywords: ribosomally synthesized; modified peptides; translationally modified; post translationally ... See more keywords
Synthesis of Ribosomally Synthesized and Post-Translationally Modified Peptides Containing C-C Cross-Links.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00508
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are known for their macrocyclic structures, which impart unique biological activity. One rapidly emerging subclass of RiPP natural products contains macrocyclic C-C cross-links between two amino acid side… read more here.
Keywords: cross links; ribosomally synthesized; modified peptides; translationally modified ... See more keywords
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b01519
Abstract: Recently developed bioinformatic tools have bolstered the discovery of ribosomally synthesized and post-translationally modified peptides (RiPPs). Using an improved version of Rapid ORF Description and Evaluation Online (RODEO 2.0), a biosynthetic gene cluster mining algorithm,… read more here.
Keywords: translationally modified; post translationally; thioether; ribosomally synthesized ... See more keywords
Synthesis of Side-Chain Modified Peptides Using Iterative Solid Phase ‘Click’ Methodology
Sign Up to like & getrecommendations! Published in 2017 at "Australian Journal of Chemistry"
DOI: 10.1071/ch16567
Abstract: A series of side-chain modified peptides have been prepared via an iterative sequence of peptide couplings and azide–alkyne cycloadditions (‘click’ reactions) using Fmoc-solid phase peptide synthesis. This efficient modular synthetic route allows the systematic and… read more here.
Keywords: chain modified; methodology; side chain; modified peptides ... See more keywords
Autoantibodies to Oxidatively Modified Peptide: Potential Clinical Application in Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12102269
Abstract: Coronary artery disease (CAD) is a global health issue. Lipid peroxidation produces various by-products that associate with CAD, such as 4-hydroxynonenal (HNE) and malondialdehyde (MDA). The autoantibodies against HNE and MDA-modified peptides may be useful… read more here.
Keywords: coronary artery; autoantibodies oxidatively; artery disease; modified peptides ... See more keywords