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   Articles with "modified release" as a keyword



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Pharmacokinetic analysis of modified‐release metoprolol formulations: An interspecies comparison

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recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2016.10.039

Abstract: &NA; In the current study, we investigated the metoprolol absorption kinetics of an in‐house produced oral sustained‐release formulation, matrices manufactured via prilling, and two commercially available formulations, ZOK‐ZID® (reservoir) and Slow‐Lopresor® (matrix) in both New… read more here.

Keywords: absorption; metoprolol; formulation; pharmacokinetic analysis ... See more keywords
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In vitro and in vivo assessment of Adansonia digitata mucilage as a matrix former in modified release tablets of metoprolol tartrate

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recommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2019.101227

Abstract: Abstract The study was aimed to investigate the ability of Adansonia digitata mucilage (ADM) a new hydrophilic plant polymeric material, in modifying metoprolol tartrate (MPT) release from matrix tablet formulations in comparison with a semi… read more here.

Keywords: modified release; metoprolol tartrate; drug; digitata mucilage ... See more keywords
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Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose

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recommendations! Published in 2017 at "Clinical Toxicology"

DOI: 10.1080/15563650.2017.1290253

Abstract: Abstract Context: The paracetamol-aminotransferase multiplication product (APAP × ALT) is a risk predictor of hepatotoxicity that is somewhat independent of time and type of ingestion. However, its accuracy following ingestion of modified-release formulations is not known, as… read more here.

Keywords: multiplication product; product; hepatotoxicity; paracetamol ... See more keywords
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Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia.

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recommendations! Published in 2023 at "European journal of endocrinology"

DOI: 10.1093/ejendo/lvac006

Abstract: OBJECTIVE Poorly controlled salt-wasting (SW) congenital adrenal hyperplasia (CAH) patients often require high 9α-fluorocortisol doses as they show high levels of 17-hydroxyprogesterone (17OHP), which is a mineralocorticoid (MC)-receptor antagonist. DESIGN We investigated the renin-angiotensin-aldosterone system… read more here.

Keywords: adrenal hyperplasia; modified release; release hydrocortisone; wasting congenital ... See more keywords
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Improved glycaemic variability and time in range with dapagliflozin versus gliclazide modified release among adults with type 2 diabetes, evaluated by continuous glucose monitoring: A 12‐week randomized controlled trial

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recommendations! Published in 2019 at "Diabetes"

DOI: 10.1111/dom.13913

Abstract: To evaluate whether there is a difference between the effects of dapagliflozin and gliclazide modified release (MR) on glycaemic variability (GV) and glycaemic control, as assessed by continuous glucose monitoring (CGM), in individuals with uncontrolled… read more here.

Keywords: glycaemic variability; gliclazide modified; type diabetes; modified release ... See more keywords
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In vitro–In vivo Relationship and Bioequivalence Prediction for Modified-Release Capsules Based on a PBPK Absorption Model

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recommendations! Published in 2019 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-019-1566-x

Abstract: A physiologically based pharmacokinetic (PBPK) absorption model was developed in GastroPlus™ based on data on intravenous, immediate-release (IR), and modified-release (MR) drug products. The predictability of the model was evaluated by comparing predicted and observed… read more here.

Keywords: pbpk absorption; model; modified release; absorption model ... See more keywords
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Physiologically Based Biopharmaceutics Model of Vildagliptin Modified Release (MR) Tablets to Predict In Vivo Performance and Establish Clinically Relevant Dissolution Specifications

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recommendations! Published in 2022 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-022-02264-2

Abstract: The objective of the study was to predict pharmacokinetic (PK) and pharmacodynamic (PD) parameters of matrix-based modified release (MR) drug product of vildagliptin. Physiologically based biopharmaceutics modeling (PBBM) was developed using GastroPlus™ based on the… read more here.

Keywords: vildagliptin; dissolution specifications; drug product; modified release ... See more keywords
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Pharmacokinetics of a Fixed-Dose Combination of Teneligliptin Hydrochloride Hydrate and Modified-Release Metformin Under Fasting and Fed Conditions in Healthy Subjects

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recommendations! Published in 2022 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s393675

Abstract: Purpose This study was performed to compare the pharmacokinetics of two fixed-dose combination (FDC) formulations of teneligliptin combined with modified-release metformin in healthy Korean subjects under fasting and fed conditions. Patients and Methods The study… read more here.

Keywords: fasting fed; modified release; fixed dose; fed conditions ... See more keywords
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Hydrogels for modified-release drug delivery systems.

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recommendations! Published in 2021 at "Current pharmaceutical design"

DOI: 10.2174/1381612828666211230114755

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4… read more here.

Keywords: delivery systems; hydrogels modified; drug delivery; modified release ... See more keywords
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Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin

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recommendations! Published in 2019 at "Current Drug Delivery"

DOI: 10.2174/1567201815666180914095701

Abstract: Objective: Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nano-fibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants. Methods: Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the… read more here.

Keywords: electrospun; mlt loaded; melatonin; modified release ... See more keywords
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Modified Release of the Pineal Hormone Melatonin from Matrix Tablets Containing Poly(L-lactic Acid) and Its PLA-co-PEAd and PLA-co-PBAd Copolymers

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recommendations! Published in 2022 at "Polymers"

DOI: 10.3390/polym14081504

Abstract: In terms of drug delivery, the attractive properties of poly(L-lactic acid) (PLA) and its aliphatic polyesters, poly(ethylene adipate) (PEAd) and poly(butylene adipate) (PBAd), render them ideal co-formulants for the preparation of modified-release pharmaceutical formulations. Furthermore,… read more here.

Keywords: poly lactic; modified release; lactic acid; pla ... See more keywords